Many Scid options and preferences (such as the board size, colors, fonts, and default settings) are adjustable from the [Options] menu. All these (and more, such as the last directory you loaded a database from and the sizes of some windows) are saved to an options file when you select Save Options from the Options menu. The options file is loaded whenever you start Scid.
If you use Windows, the options file is scid.opt in the directory where the Scid program file scid.exe is located. For users of Unix operating systems (such as Solaris or Linux) the file is ~/.scid/scidrc.
Scid has three basic fonts it uses in most of its windows, and you can customize all of them. They are called regular, small and fixed.
The fixed font should be a fixed-width (not proportional) font. It is used for the tree and crosstable windows.